Stage 3 CKD Care

Approximately 15–33% of kidney function remains.Stage 3 requires supplements, renal diet, subcutaneous fluids, electrolyte balance, and management of complications.

Supplements

A combination of multiple supplements and prescription medications are required.

✔ Core Supplement Set

  • Dr. Toru Protocol – AIM-based, supports kidney waste clearance
  • Intensive Protocol – cellular energy, AMPK activation, antioxidant support
  • Probiotics Protocol – uremic toxin reduction, gut health support

✔ Recommended Additional Supplements

  • Omega-3 (EPA/DHA, 100 mg/day) – inflammation control, improved renal blood flow
  • Melatonin (1 mg/day) – supports anemia prevention

✔ Veterinary Prescription Medications

  • Phosphate binders (e.g., Sevelamer, Lanthanum) – bind and remove excess phosphorus
  • Uremic toxin binders (e.g., activated charcoal) – absorb and eliminate toxins

Diet

Only renal prescription diets should be given.

✔ Assisted Feeding

  • Self-feeding often becomes difficult in Stage 3.
  • Rather than waiting and risking further deterioration, early assisted feeding is strongly recommended.

✔ Methods of Assisted Feeding

  • Drop small kibbles of renal dry food into the cat’s mouth with the head tilted upward, allowing gravity to guide ingestion (most recommended)
  • Blend renal wet food and feed using a syringe (※ Be careful to avoid aspiration)

※ Appetite stimulants (e.g., Mirtazapine) may be effective short term, but prolonged use can cause agitation and place strain on the heart and blood pressure—use with caution.

Subcutaneous Fluids (Sub-Q)

Daily subcutaneous fluid administration is required under veterinary supervision.

※ Caution is needed if the cat has heart or lung conditions.

✔ Dosage guideline:

  • 40–50 ml(1.35–1.7 fl oz) per 1 kg(2.2 lb) of body weight per day
  • Example: 4 kg (9 lb) cat → 160–200 ml/day (5.4–6.8 fl oz/day)

✔ Commonly used fluids:

  • Hartmann’s Solution
  • Normal Saline (NaCl 0.9%)
  • Plasma-Lyte

Electrolytes

In Stage 3, blood tests should monitor and manage the following:
Phosphorus (P), Potassium (K⁺), Calcium (Ca²⁺), Bicarbonate (HCO₃⁻), Sodium (Na⁺)

✔ Elevated P – Hyperphosphatemia

  • Common in Stage 3 CKD.
  • Administer phosphate binders with food.
    → e.g., Sevelamer, Lanthanum

✔ Low HCO₃⁻ – Metabolic Acidosis

  • Blood pH becomes acidic, disrupting electrolyte balance.
  • Supplement with Sodium Bicarbonate
    → Helps alkalize blood and stabilize electrolytes

✔ Elevated K⁺ or Ca²⁺ – Hyperkalemia / Hypercalcemia

  • Often occurs with persistent low HCO₃⁻ and acidosis.
    → Correct with Sodium Bicarbonate supplementation

✔ Low K⁺ – Hypokalemia

  • Caused by excessive urinary potassium loss.
  • Supplement with potassium products
    → e.g., Potassium Gluconate, Potassium Citrate

✔ High Na⁺ – Hypernatremia

  • Adjust by switching to low-sodium fluids.
    → Replace NaCl 0.9% with Hartmann’s Solution (Lactated Ringer’s)

Kidney Checkpoints

Complications such as anemia, hypertension, and HCM (hypertrophic cardiomyopathy) may develop. During veterinary visits, regularly check the following:

✔ Every 2 weeks to 1 month:

  • Creatinine, BUN, Phosphorus
  • Electrolytes, Bicarbonate (HCO₃⁻): assess for acidosis
  • HCT/RBC: check for anemia

✔ Every 3 months:

  • Blood pressure (monitor for hypertension)
  • proBNP (a biomarker indicating cardiac stress)
  • Chest X-ray or auscultation (check for pulmonary edema or cardiac abnormalities)

Emergency Symptom Checklist

If your cat shows any of the following signs, seek veterinary care immediately:

  • Complete loss of appetite
  • Vomiting more than 3 times a day
  • Extreme lethargy or unsteady gait
  • Open-mouth breathing or difficulty breathing
  • No bowel movement for over 48 hours
  • Persistent straining to urinate or defecate every 5 minutes

When to Consider Changing Clinics

If your current veterinary clinic responds in the following ways during Stage 3, it may be time to seek a second opinion:

  • Does not offer or prescribe subcutaneous fluids
  • Fails to explain or address metabolic acidosis (low HCO₃⁻)
  • States “there’s nothing more we can do” without attempting combination treatment

Summary – Stage 3 Care

✔ Supplement Protocol

  • AIM + AMPK + Probiotics + Omega-3 + Melatonin

✔ Diet

  • Feed renal prescription diet; initiate assisted feeding if needed

✔ Subcutaneous Fluids

  • Daily Sub-Q fluids under veterinary supervision

Complete Your Cat Care Routine

Before & After on the Greycoat Program

These are real cases where the Greycoat Program was applied—especially in Stage 2 and 3 cats, when guardians were searching for a better way forward.
Take a look and see what parts of their journey might help shape your own routine.

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— Greycoat Research

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